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Advanced Bisphosphonate Therapy for Navicular Syndrome in Horses

Tildren (tiludronate disodium) is a veterinary medicine belonging to the bisphosphonate class. It is indicated for the control of clinical signs associated with navicular syndrome in horses by helping regulate excessive bone resorption and supporting healthier bone remodeling.

At Equines Vet Care, we supply genuine equine veterinary medicines sourced from trusted manufacturers to ensure quality, authenticity, and dependable care for veterinarians, trainers, breeders, and horse owners.

What is Tildren?

Tildren contains tiludronate disodium, a bisphosphonate that binds to areas of active bone remodeling. It works by modulating excessive osteoclast activity, helping restore balance between bone resorption and bone formation. This mechanism assists in reducing the clinical signs associated with navicular syndrome in affected horses.

Tildren is approved for horses only and should be administered exclusively by or under the supervision of a licensed veterinarian.

Key Features

Proven Bisphosphonate Therapy

Contains tiludronate disodium, a bisphosphonate developed to regulate excessive bone resorption in horses.

Indicated for Navicular Syndrome

Approved for the control of clinical signs associated with navicular syndrome, particularly when used as part of a comprehensive management plan that includes corrective farriery where appropriate.

Long-Lasting Action

Following intravenous infusion, tiludronate binds to bone remodeling sites and may continue to exert effects for months as bone remodels.

Veterinary Prescription Medicine

Available only for professional veterinary use and administered by intravenous infusion according to approved prescribing information.

Benefits

• Helps control clinical signs associated with navicular syndrome
• Supports healthier bone remodeling
• Helps reduce pain associated with abnormal bone resorption
• Long-acting bisphosphonate therapy
• May improve comfort and mobility when used as part of a comprehensive veterinary treatment plan
• Suitable for horses under veterinary supervision

Common Veterinary Applications

Veterinarians may prescribe Tildren for:

• Navicular syndrome
• Navicular-associated lameness
• Bone remodeling disorders where approved by local regulations

In some countries, tiludronate products are also approved for bone spavin (hock osteoarthritis), depending on the regional product registration. Always follow the approved labeling in your country.

Active Ingredient

Each vial contains:

• Tiludronate Disodium (equivalent to 500 mg tiludronic acid)

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When you purchase from Equines Vet Care, you receive:

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Frequently Asked Questions

What is Tildren used for?

Tildren is indicated for the control of clinical signs associated with navicular syndrome in horses by helping normalize excessive bone remodeling.

How does Tildren work?

Tiludronate binds to actively remodeling bone and modulates excessive osteoclast activity, helping reduce abnormal bone resorption while allowing healthier remodeling.

How is Tildren administered?

Tildren is administered as a slow intravenous infusion by a licensed veterinarian. The infusion is typically given over approximately 90 minutes according to the approved product label.

Are there any precautions?

Yes. Horses should be well hydrated before treatment. Tildren should not be used in horses with impaired renal function, and concurrent administration with NSAIDs should generally be avoided because of the increased risk of kidney toxicity. Horses should also be monitored after infusion, as transient signs of colic may occur.

Is Tildren a prescription medicine?

Yes. Tildren is a prescription-only veterinary medicine and should only be administered under veterinary supervision.

Can competition horses receive Tildren?

Competition rules and medication withdrawal periods vary among racing and equestrian organizations. Owners should consult their veterinarian and the relevant governing authority before administering Tildren to a competition horse.

Storage Instructions

• Store at controlled room temperature according to the manufacturer’s recommendations before reconstitution.
• After preparation, administer promptly or refrigerate only as directed in the product labeling.
• Protect from light after reconstitution.
• Keep out of reach of children and animals.

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Equines Vet Care is committed to providing:

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• Products sourced from trusted veterinary manufacturers

Buy Tildren for Horses Online

Tildren is a proven tiludronate disodium bisphosphonate therapy for horses with navicular syndrome, helping regulate abnormal bone remodeling and improve clinical comfort as part of a comprehensive veterinary treatment plan. Because it is a prescription medicine with important administration and safety considerations, it should always be used under the guidance of a licensed veterinarian.

Order Tildren for Horses today from Equines Vet Care and shop with confidence for genuine veterinary medicines, secure online ordering, competitive pricing, and reliable worldwide delivery where legally permitted.

Tildren for Horses indicated for the control of clinical signs associated with navicular syndrome in horses. It is a bisphosphonate drug for intravenous infusion. Each 30 ml vial contains a sterile powder of 500 mg tiludronic acid (as tiludronate disodium) and 250 mg mannitol USP. Buy Tildren for Horses Online from us at very competitive prices. Tildren for Horses is a prescription medication formulated to help horses control symptoms associated with navicular syndrome. This degenerative

condition typically causes pain in the heel of the horse’s front feet, where the navicular bone is located. Horses can experience pain from changes in the bones, tendons, ligaments and bursa—the joint structures that are filled with fluid.

This pain can result in lameness, which causes the horse to move abnormally by overcompensating for the affected area. Tildren helps to restore balance to the bone remodeling process, which replaces old bone tissue with new tissue.

Uses
Tildren for Horses is indicated for the control of clinical signs associated with navicular syndrome in horses. Navicular syndrome is the most common cause of chronic forelimb lameness in performance horses. It is a degenerative process instigated by mechanical forces. Buy Tildren for Horses Infusion.

Possible Side Effects
Do not use in horses with impaired renal function or with a history of renal disease. Bisphosphonates are excreted by the kidney; therefore, conditions causing renal impairment may increase plasma bisphosphonate concentrations resulting in an increased risk for adverse reactions. Do not use in horses with known hypersensitivity to tiludronate disodium or to mannitol.

Drug & Food Interactions
NSAIDs should not be used concurrently with Tildren for Horses. Concurrent use of NSAIDs with Tildren may increase the risk of renal toxicity and acute renal failure.

Precautions
NSAIDs should not be used concurrently with Tildren. Concurrent use of NSAIDs with Tildren may increase the risk of renal toxicity and acute renal failure. The safe use of Tildren has not been evaluated in horses less than 4 years of age. Bisphosphonates should not be used in pregnant or lactating mares, or mares intended for breeding.

Recommended Dosage
A single dose of Tildren should be administered as an intravenous infusion at a dose of 1 mg/kg (0.45 mg/lb). The infusion should be administered slowly and evenly over 90 minutes to minimize the risk of adverse reactions. Maximum effect may not occur until 2 months post-treatment.

Storage Instructions
Sterile powder (not reconstituted): Store at controlled room temperature 68-77° F (20-25° C). After preparation, the infusion should be administered either within 2 hours of preparation, or it can be stored for up to 24 hours under refrigeration at 36-46° F (2-8° C) and protected from light.

Dosing Instructions
Step 1: Preparation of the reconstituted solution (20 mg/mL). Tildren for Horses should be reconstituted using strict aseptic technique. Remove 25 mL of solution from a 1-liter bag of sterile 0.9% Sodium Chloride Injection, USP and add it to one vial of Tildren for Horses. Shake gently until the powder is completely dissolved. This reconstituted solution contains 20 mg of tiludronate disodium per mL. After reconstitution further dilution is required before administration.

Step 2: Preparation of the solution for infusion. Using strict aseptic technique, withdraw the appropriate volume of the reconstituted solution based on the horse’s body weight (see Table 1 below). Inject that volume back into the 1 liter bag of sterile 0.9% Sodium Chloride Injection, USP.

Horses greater than 1,210 lbs. will require a second vial of reconstituted Tildren for Horses solution. Invert the infusion bag to mix the solution before infusion.

Label the infusion bag to ensure proper use. After preparation, the infusion should be administered either within 2 hours of preparation, or it can be stored for up to 24 hours under refrigeration at 36-46° F (2-8° C) and protected from light.

Step 3: Administer for infusion through a suitable intravenous catheter inserted into a jugular vein and connected to the infusion bag using sterile disposable infusion tubing.

Do not reconstitute or mix Tildren for Horses with calcium containing solutions or other solutions containing divalent cations such as Lactated Ringers as it may form complexes with these ions