ReCovr Injection for Horses and Cattle

Recover Injection for use in horses and cattle in conditions in which antihistamine therapy may be expected to lead to alleviation of some signs of disease. Not for use in beef calves less than 2 months of age, dairy calves, and veal calves. 20 mg/ml. Tripelennamine hydrochloride.

Directions for Use:
Horses: Administer intramuscularly only at a dose of 0.5 mg per lb. of body weight (2.5 mL for each 100 lbs. of body weight). This dose may be repeated in 6-12 hours if necessary.

Cattle: Administer intravenously or intramuscularly at a dose of 0.5 mg per lb. of body weight (2.5 mL for each 100 lbs. of body weight). This dose may be repeated in 6-12 hours if necessary. The intravenous route of administration may provide a more rapid onset of action. Use aseptic technique to administer ReCovr Injection (tripelennamine hydrochloride injection).

$102.89

Compare

Add to wishlist

Guaranteed Safe Checkout

Description, Features & Compatibility

Buy ReCovr Injection (Tripelennamine Hydrochloride) 20mg/ml Injection Online: The Definitive Veterinary Guide to Competitive $H_1$ Receptor Antagonism, Anaphylactic Emergency Stabilization, and Histamine Mediated Disease Therapy in Equine and Bovine Patients

Managing acute allergic hypersensitivity, anaphylactic reactions, urticaria (hives), toxic shock, and inflammatory pulmonary disorders in horses and cattle demands an immediate systemic therapeutic response. When an animal encounters environmental allergens, insect bites, vaccine sensitization, moldy feed toxins, or acute bacterial metritis/mastitis, massive quantities of histamine are released from tissue mast cells and circulating basophils into systemic circulation.

Once released, histamine binds rapidly to capillary $H_1$ receptors, inducing sudden vasodilation, profound vascular permeability, severe airway smooth muscle constriction, bronchospasm, skin wheals, and acute hypotension.

In severe cases, acute histamine release can progress to fatal anaphylactic shock or severe pulmonary edema if competitive receptor blockade is delayed.

To halt the histamine cascade instantly and restore normal vascular and airway tone, large animal veterinarians depend on rapid-acting parenteral antihistamines. Re-Covr Injectable Solution (manufactured by KineticVet) is a premier, FDA-approved injectable antihistamine engineered specifically for equine and bovine medicine. Powered by Tripelennamine Hydrochloride at a concentration of $20\ \text{mg/mL}$ , ReCovr Injection acts as a potent, competitive antagonist at histamine $H_1$ receptor sites, rapidly reversing histamine-mediated bronchoconstriction, tissue swelling, and systemic allergic stress.

This comprehensive clinical manual covers tripelennamine $H_1$ receptor pharmacodynamics, species-specific administration routes, clinical emergency applications, and precise dosing guidelines for ReCovr Injection.

Molecular Pharmacodynamics & $H_1$ Receptor Blockade Kinetics

Re-Covr delivers a rapid, competitive receptor-level blockade that neutralizes circulating histamine activity:

                        [Histamine Released from Mast Cells / Basophils]
                                              |
                        [ReCovr Injection (Tripelennamine HCl) Administered]
                                              |
                   [Competitive Binding to Systemic H1 Receptors]
                                              |
                 -------------------------------------------------
                |                                                 |
       [VASCULAR SHIELD]                                 [AIRWAY & TISSUE SHIELD]
     (Prevents Vasodilation)                           (Blocks Smooth Muscle Constriction)
                |                                                 |
                v                                                 v
   [Blocks Capillary Permeability]                    [Relieves Severe Bronchospasm & Wheezing]
   (Reduces Hives, Edema, & Swelling)                 (Restores Normal Pulmonary Gas Exchange)
                |                                                 |
                v                                                 v
   [Stabilizes Intravascular Blood Pressure]          [Halts Systemic Anaphylactic Shock]
                |                                                 |
                 ------------------------> <----------------------
                                        |
                                        v
                    [Rapid Recovery from Acute Allergic Emergencies]
                                        |
                    [Restoration of Normal Respiratory & Cutaneous Function]

Competitive $H_1$ Receptor Antagonism

Tripelennamine Hydrochloride ( $20\ \text{mg/mL}$ ) is an ethylenediamine derivative belonging to the first-generation antihistamine class. It acts through competitive antagonism by reversibly binding to cellular histamine $H_1$ receptors on target tissues. By occupying these receptors before or as histamine is released, tripelennamine prevents histamine from activating the signaling pathways that cause pathological tissue changes.

Physiological Effects of Tripelennamine

Vascular Permeability Suppression: Stops the leakage of fluid from small capillaries into tissues, rapidly reducing cutaneous wheals (hives), facial edema, and pulmonary fluid buildup.
Bronchial Smooth Muscle Relaxation: Prevents histamine-induced airway constriction, allowing bronchioles to dilate and restoring normal respiratory airflow during acute allergic dyspnea.
Anti-Pruritic Action: Blocks local nerve ending irritation, relieving intense itching and skin agitation associated with insect hypersensitivity or feed reactions.

Core Species Clinical Indications

ReCovr Injection 20mg/ml is a vital emergency and maintenance therapeutic tool in equine sports medicine and livestock production:

Equine Clinical Indications

Allergic Dermatitis & Urticaria (Hives): Rapidly clears acute skin wheals, facial angioedema, and allergic hives caused by insect bites, chemicals, or feed hypersensitivities.
Anaphylactic Shock: Stabilizes horses suffering acute anaphylactic shock secondary to drug reactions, vaccines, or venomous stings.
Inhalant Allergies & Heaves (RAO/EAHO): Adjunctive therapy for acute allergic respiratory distress and bronchospasm associated with moldy hay or dusty environments.

Bovine Clinical Indications

Acute Bovine Pulmonary Emphysema (Fog Fever): Relieves severe respiratory distress caused by sudden pasture changes.
Toxic Metritis & Toxic Mastitis Adjunct: Counteracts massive systemic histamine release associated with acute coliform mastitis or retained placenta.
Bloat & Grain Overload (Rumen Acidosis): Mitigates histamine toxicity generated during severe ruminal lactic acidosis.
BRD / Shipping Fever Adjunct: Reduces airway inflammation and pulmonary exudate in cattle suffering from acute bovine respiratory disease.

Recommended Administration and Dosing Protocols

To guarantee rapid onset while maintaining physiological safety, ReCovr Injection must be administered strictly according to species-approved injection routes.

1.Determine Approved Injection Route by Species:Route Identification.

Horses: Formulated strictly for Intramuscular (IM) injection. Do not give IV.
Cattle: Approved for Intravenous (IV) or Intramuscular (IM) injection.

2.Calculate Precise Volumetric Requirement:Dosage Calculation.

The standard clinical dose for both horses and cattle is 0.5 mg per lb body weight ( $2.5\ \text{mL}$ per $100\ \text{lbs}$ / $45\ \text{kg}$ body weight).

3.Administer Slowly & Observe Volume Limits:Technique & Speed.

When giving IV to cattle, inject very slowly. For IM administration in horses or cattle, split large volumes across separate injection sites to ensure comfort.

4.Assess Response & Repeat Dosing as Needed:Re-evaluation Window.

Treatment may be repeated every 6 to 12 hours as indicated by clinical signs until allergic symptoms completely resolve.

Species Dosage and Administration Reference Table

The table below outlines standard clinical dosing parameters for Re-Covr Injectable Solution ( $20\ \text{mg/mL}$ ):

Target Species	Active Dosage Rate	Volumetric Dosing Ratio	Approved Route	Dosing Interval	Milk / Slaughter Withdrawal
Horses	$0.5\ \text{mg/lb}$ ( $1.1\ \text{mg/kg}$ )	$2.5\ \text{mL}$ per $100\ \text{lbs}$ ( $45\ \text{kg}$ )	IM Only	Repeat q6-12h as needed	N/A (Non-Food Equine)
Beef Cattle	$0.5\ \text{mg/lb}$ ( $1.1\ \text{mg/kg}$ )	$2.5\ \text{mL}$ per $100\ \text{lbs}$ ( $45\ \text{kg}$ )	IV or IM	Repeat q6-12h as needed	4 Days Slaughter
Dairy Cattle	$0.5\ \text{mg/lb}$ ( $1.1\ \text{mg/kg}$ )	$2.5\ \text{mL}$ per $100\ \text{lbs}$ ( $45\ \text{kg}$ )	IV or IM	Repeat q6-12h as needed	24 Hours Milk / 4 Days Slaughter

Clinical Safety, Regulatory Compliance, and Storage

Strict Equine Route Warning: ReCovr Injection must be given Intramuscularly (IM) in horses. Intravenous injection in horses can cause central nervous system stimulation, violent hyperexcitability, muscle tremors, seizures, and collapse.
Cattle IV Administration Precautions: When administering intravenously to cattle, inject very slowly. Rapid IV bolus administration can trigger temporary nervousness or muscle twitching.
Withdrawal Periods for Cattle:
- Milk Withholding: 24 hours (2 milkings) after last injection.
- Slaughter Withdrawal: 4 days after last injection.
Central Nervous System Effects: Drowsiness or mild sedation may occur in some animals following therapeutic doses. Conversely, high doses may induce transient CNS excitement.
Storage Parameters: Store at controlled room temperature between 20°C and 25°C (68°F to 77°F). Protect from direct light exposure and freezing.

ReCovr Injection Frequently Asked Questions (FAQ)

Can ReCovr Injection be injected intravenously (IV) in horses?

No. ReCovr Injection is approved strictly for Intramuscular (IM) injection in horses. Intravenous administration in horses can cause acute central nervous system stimulation, severe hyperexcitability, or seizures.

How fast does ReCovr Injection begin working after injection?

Following intramuscular administration, tripelennamine hydrochloride is absorbed rapidly, providing clinical relief from hives and bronchospasm within 20 to 30 minutes. Intravenous administration in cattle provides near-instantaneous relief.

What is the slaughter and milk withdrawal period for cattle treated with ReCovr Injection?

Cattle treated with ReCovr Injection have a 24-hour milk withdrawal period and a 4-day slaughter withdrawal period.

Where can I buy genuine ReCovr Injection online?

You can safely purchase authentic, factory-sealed Re-Covr Injectable Solution online through Equines Vet Care. We store and manage all inventory under strict environmental controls to guarantee absolute product stability and full therapeutic potency.

Secure Premium Sourcing from Equines Vet Care

At Equines Vet Care, we understand that treating acute allergic and systemic emergencies requires absolute product reliability. Every vial of ReCovr Injection (Tripelennamine HCl) 20mg/ml Injection is sourced through authorized veterinary distribution networks, stored in our climate-controlled facility, and shipped securely to ensure complete product quality.

For wholesale veterinary clinic accounts, farm supply orders, or logistics tracking assistance, please reach out to our professional support desk directly at our contact us page.

Additional information

Trusted Feedback

Reviews

There are no reviews yet.

Be the first to review “ReCovr Injection for Horses and Cattle”

$57.00