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Loncor 300 (Florfenicol) Injectable Solution for Cattle

Name: Loncor 300 (Florfenicol) Injectable Solution for Cattle - Buy Veterinary Medicines Online for Horses, Pets & Livestock at Equines Vet Care with Worldwide Shipping
Price: 195.00 USD
Availability: InStock

Loncor 300 (Florfenicol) Injectable Solution for Cattle is an antibiotic indicated for the treatment of bovine respiratory disease (BRD) and foot rot, and for the control of respiratory disease in cattle at high risk for developing BRD in beef and non-lactating dairy cattle. Each ml of BRD antibiotic, Loncor 300 Injectable Solution, contains 300 mg florfenicol and can be administered subcutaneously or intramuscularly. For treatment of BRD or foot rot, the recommended dosage is 3 ml per 100 lbs. body weight, given by IM injection. A second dose should be given 48 hours later. Alternatively, Loncor 300 can be administered once by SQ injection of 6 ml per 100 lbs. For control of respiratory disease in cattle at high risk for BRD, administer 6 ml per 100 lbs., given SQ in the neck. Do not administer more than 10 ml per injection site. The injection should be given only in the neck. For use in beef and non-lactating dairy cattle only. Not for use in female dairy cattle 20 months of age or older, including dry dairy cows. Do not use in calves to be processed for veal. Florfenicol.

Original price was: $200.00.Current price is: $195.00.

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Description, Features & Compatibility

Buy Loncor 300 Solution 250ml Online: The Definitive Veterinary Guide to Florfenicol Ribosomal Inhibition Kinetics, Bovine Respiratory Disease Treatment, Foot Rot Care, and Livestock Health

Managing acute respiratory outbreaks, bovine respiratory disease (BRD) complexes, shipping fever, and interdigital phlegmon (foot rot) in beef and non-lactating dairy cattle requires a broad-spectrum, high-potency synthetic antimicrobial. When cattle experience high-stress feedlot arrival, transportation trauma, or abrupt weather shifts, bacterial pathogens multiply rapidly within pulmonary tissues, causing severe consolidation, fever, and systemic distress.

Left unmanaged, respiratory complexes and acute bacterial outbreaks spread rapidly through livestock herds, resulting in high morbidity, permanent lung damage, reduced weight gains, and heavy economic losses.

Relying on outdated, bacteriostatic antibiotics that only slow bacterial growth is often insufficient during aggressive respiratory epidemics.

To provide powerful, sustained bactericidal action and deep tissue penetration across pulmonary and systemic sites at an economical volume, veterinarians and professional livestock producers rely on gold-standard florfenicol solutions. Loncor 300 Injectable Solution (250ml) is a premier, professional-grade broad-spectrum antimicrobial formulation powered by Florfenicol at a robust concentration of $300\ \text{mg/mL}$ . Packaged in an economical $250\ \text{ml}$ multi-dose glass vial, Loncor 300 delivers targeted, long-acting antibacterial potency engineered specifically for cattle health management.

Florfenicol Pharmacology & Antimicrobial Kinetics

Loncor 300 delivers a targeted biochemical mechanism engineered to inhibit bacterial protein synthesis while maintaining prolonged therapeutic concentrations:

                  [Loncor 300 300mg/mL Solution Administered (IM or SQ)]
                                             |
                  [Rapid Systemic Absorption into Blood Plasma Pools]
                                            |
               [Binding to the 50S Ribosomal Subunit of Pathogenic Bacteria]
                                            |
               -------------------------------------------------
              |                                                 |
     [BLOCKS PEPTIDYL TRANSFERASE]               [SUSTAINED TISSUE CONCENTRATIONS]
   (Inhibits Bacterial Protein Synthesis)       (Maintains Deep Pulmonary & Nasal Penetration)
              |                                                 |
              v                                                 v
   [Stops Bacterial Elongation & Growth]        (Neutralizes Mannheimia, Pasteurella, & Histophilus)
   (Bacteriostatic / Bactericidal Action)       (Rapid Resolution of Consolidation & Fever)
              |                                                 |
              v                                                 v
   [Allows Host Immune Clearance]               [Prevents Relapse with Prolonged Activity]
              |                                                 |
               =========================> <=====================
                                            |
                                            v
                   [Complete Eradication of Target Livestock Pathogens]
                                            |
                   [Rapid Restoration of Herd Vigor, Respiratory Health, & Productivity]

1. Inhibition of Bacterial Protein Synthesis (50S Ribosomal Binding)

Florfenicol ( $300\ \text{mg/mL}$ ) is a synthetic, broad-spectrum fluorinated derivative of chloramphenicol. It exerts its antimicrobial action by binding to the $50\text{S}$ ribosomal subunit of susceptible bacteria, inhibiting the enzyme peptidyl transferase and preventing amino acid chain elongation. This halts bacterial protein synthesis and stops cellular replication.

2. Sustained-Action Pharmacokinetics and Tissue Diffusion

Prolonged Systemic Persistence: Designed to maintain effective therapeutic concentrations in blood plasma and target tissues for extended periods following intramuscular or subcutaneous administration.
Targeted Pulmonary and Soft-Tissue Penetration: Diffuses rapidly and extensively into lung parenchyma, bronchial secretions, and ocular tissues, successfully neutralizing major bovine respiratory pathogens including Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Fusobacterium necrophorum.

Primary Clinical & Livestock Health Indications

Loncor 300 Solution 250ml is an essential therapeutic tool across beef ranches, large feedlots, and non-lactating dairy operations:

Bovine Respiratory Disease (BRD / Shipping Fever): Treatment of respiratory infections associated with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni.
BRD Metaphylaxis (High-Risk Herds): Control of respiratory disease outbreaks in groups of beef and non-lactating dairy cattle experiencing high-stress environmental transit.
Acute Foot Rot (Interdigital Necrobacillosis): Rapidly resolves acute foot rot and associated lameness caused by Fusobacterium necrophorum and Bacteroides melaninogenicus.

Recommended Administration and Dosing Protocols

To guarantee safety, proper bioavailability, and sustained therapeutic blood levels, Loncor 300 must be administered strictly according to approved route and weight guidelines.

1.Confirm Administration Route:Route Selection.

Select the preferred administration route for cattle:

Intramuscular (IM): Administered in the neck muscle at $20\ \text{mg/kg}$ ( $3\ \text{mL}$ per $100\ \text{lbs}$ ), repeated in 48 hours.
Subcutaneous (SQ): Administered as a single high-dose treatment at $40\ \text{mg/kg}$ ( $6\ \text{mL}$ per $100\ \text{lbs}$ ) for sustained coverage.

2.Calculate Precise Body Weight Dose:Dosage Calculation.

Calculate volume strictly by body weight. For the SQ single-dose regimen, measure $6\ \text{mL}$ for every $100\ \text{lbs}$ of body weight.

3.Observe Site Volume Limits:Injection Limits.

To ensure proper absorption and tissue safety, do not inject more than $10\ \text{mL}$ per injection site. Divide larger total doses across multiple sites in the neck only.

4.Use Proper Needle Gauge:Needle Selection.

Use sterile needles appropriate for oil-based viscous solutions (typically 16-gauge).

Dosing Reference Table

The table below outlines standard administration guidelines for Loncor 300 Solution ( $300\ \text{mg/mL}$ ):

Regimen Schedule	Dosage Rate per Pound	Volume per 100 lbs	Approved Route	Administration Frequency
Intramuscular (IM) Regimen	$9.0\ \text{mg/lb}$ ( $20\ \text{mg/kg}$ )	$3.0\ \text{mL}$ per $100\ \text{lbs}$	Intramuscular (IM) in Neck	First injection, repeated 48 hours later
Subcutaneous (SQ) Single Dose	$18.0\ \text{mg/lb}$ ( $40\ \text{mg/kg}$ )	$6.0\ \text{mL}$ per $100\ \text{lbs}$	Subcutaneous (SQ) in Neck	Single-dose treatment (no second injection)

Clinical Safety, Restrictions, and Storage

Strictly Non-Lactating Cattle Only: Do not use in female dairy cattle 20 months of age or older or in calves to be processed for veal. Use in lactating dairy cattle may cause drug residues in milk. Approved strictly for beef cattle and non-lactating dairy stock.
Meat Withdrawal Periods: Always adhere strictly to regional regulatory withdrawal windows prior to marketing animal products for human consumption. Note: Cattle treated via the IM regimen carry a 28-day meat withdrawal, while cattle treated via the single SQ high-dose regimen carry a 38-day meat withdrawal.
Storage Parameters: Store unopened $250\ \text{ml}$ multi-dose glass vials at controlled room temperature between 15°C and 30°C (59°F to 86°F). Protect from direct sunlight and freezing. Use broached vials within standard aseptic timeframes.

Frequently Asked Questions (FAQ)

What is the active ingredient in Loncor 300 250ml?

Loncor 300 contains Florfenicol at a concentration of $300\ \text{mg/mL}$ , functioning as a synthetic broad-spectrum antibacterial agent.

Can Loncor 300 be used in lactating dairy cows?

No. Loncor 300 is strictly contraindicated in female dairy cattle 20 months of age or older and lactating dairy cows. It is approved exclusively for beef cattle and non-lactating dairy stock.

What is the advantage of the $250\ \text{ml}$ bottle size?

The economical $250\ \text{ml}$ multi-dose vial provides an ideal volume for larger feedlot operations and ranches treating multiple head of cattle, reducing vial changes and ensuring ample supply on hand.

Where can I buy genuine Loncor 300 250ml online?

You can safely purchase authentic, factory-sealed Loncor 300 Injectable Solution (250ml vials) online through Equines Vet Care. We manage and store all veterinary pharmaceutical inventory under strict environmental controls to guarantee absolute product freshness, safety, and full potency.

Secure Premium Sourcing from Equines Vet Care

At Equines Vet Care, we understand that managing respiratory outbreaks, shipping fever, and foot rot across large cattle herds requires absolute product reliability and value. Every $250\ \text{ml}$ vial of Loncor 300 Solution is sourced through authorized veterinary distribution networks, stored in our climate-controlled warehouse, and shipped securely to ensure complete product quality.

BRD Treatment – Loncor 300 Injectable Solution is indicated for treatment of bovine respiratory disease (BRD), associated with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni.

Foot Rot Treatment – Loncor 300 Injectable Solution is indicated for the treatment of bovine interdigital phlegmon (foot rot, acute interdigital necrobacillosis, infectious pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.

BRD Control – Loncor 300 Injectable Solution is also indicated for the control of respiratory disease in cattle at high risk of developing BRD associated with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni.