



Pradalex Injectable (pradofloxacin) from Elanco is a convenient, one-shot, low-volume antibiotic for cattle and swine which has a 2-day withdrawal period and features a unique molecular structure and a mode of action which simultaneously blocks two enzymes responsible for bacterial replication within the bacteria nucleus. Effective BRD/SRD treatment after consideration of other non-fluoroquinolone therapeutic options. This antibiotic treatment achieves peak serum activity within 45 minutes following injection. Pradalex Injectable treats BRD associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis in cattle intended for slaughter (beef calves 2 months of age and older, growing beef steers, growing beef heifers, and beef bulls intended for slaughter), and in cattle intended for breeding less than 1 year of age (replacement beef and dairy heifers less than 1 year of age, and beef and dairy bulls less than 1 year of age).
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Managing aggressive respiratory outbreaks, bovine respiratory disease (BRD) complexes, swine respiratory disease (SRD), and acute bacterial lung infections in cattle and swine herds requires a cutting-edge, high-potency antimicrobial. When livestock encounter complex multi-pathogen respiratory challenges—such as Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, Mycoplasma bovis, Glaesserella parasuis, and Actinobacillus pleuropneumoniae—traditional single-enzyme antibiotics often struggle to halt rapid cellular replication and tissue consolidation.
Left unmanaged, severe respiratory epidemics lead to high herd morbidity, permanent pulmonary scarring, heavy treatment failures, and extensive economic losses across feedlots and production units.
Relying on older, time-dependent antimicrobial classes increases the window for resistance selection and prolongs clinical recovery intervals.
To deliver revolutionary, concentration-dependent bactericidal eradication with a dual molecular target and exceptionally short withdrawal times, professional veterinarians and commercial producers rely on the newest class-defining fluoroquinolone. Pradalex Injectable (100ml) (manufactured by Elanco Animal Health) is an innovative, third-generation fluoroquinolone solution containing $200\ \text{mg/mL}$ of pradofloxacin. Packaged in a sterile $100\ \text{ml}$ multi-dose vial, Pradalex delivers unmatched antimicrobial power engineered specifically for modern beef cattle and weaned swine operations.
Pradalex delivers a breakthrough biochemical mechanism engineered to simultaneously disrupt two vital bacterial enzyme systems, ensuring comprehensive cell destruction:
[Pradalex 100ml Injection Administered (SQ Cattle / IM Swine)]
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[Rapid Systemic Absorption (Peak Plasma within 45 Minutes)]
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[Simultaneous Dual Inhibition of DNA Gyrase & Topoisomerase IV]
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[BLOCKS DNA UNWINDING] [BLOCKS DNA DAUGHTER SEPARATION]
(Inhibits DNA Gyrase Enzyme) (Inhibits Topoisomerase IV Enzyme)
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v v
[Stops Bacterial Transcription] [Prevents Sister Cell Division]
(Neutralizes Resting & Growing Pathogens) (Induces Rapid Chromosomal Fragmentation)
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v v
[Short Mutant Selection Window (MSW)] [Rapid Resolution of Pulmonary Inflammation]
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v
[Complete Bactericidal Eradication of Livestock Pathogens]
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[Rapid Restoration of Herd Health, Normal Feed Intake, & Peak Performance]
Pradofloxacin ($200\ \text{mg/mL}$) is a breakthrough third-generation fluoroquinolone. While traditional fluoroquinolones act primarily on DNA gyrase, pradofloxacin uniquely exhibits equal high affinity for both DNA gyrase and topoisomerase IV in both gram-negative and gram-positive pathogens. By simultaneously blocking DNA unwinding and sister cell separation, Pradalex triggers rapid chromosomal fragmentation and irreversible cell death across both resting and actively dividing bacteria.
Ultrafast Systemic Uptake: Reaches peak therapeutic serum levels in as little as 45 minutes post-injection and concentrates heavily within lung pulmonary epithelial lining fluid.
Narrow Mutant Selection Window ($\text{MSW}$): Spends minimal time in the mutation-selection window, significantly reducing the probability of resistance development and supporting judicious antimicrobial stewardship.
Pradalex Injectable 100ml is an essential therapeutic tool for modern beef feedlots, cow-calf operations, and commercial swine units:
Bovine Respiratory Disease (BRD): Treatment of BRD associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis in eligible beef and dairy cattle.
Swine Respiratory Disease (SRD): Treatment of bacterial swine respiratory disease associated with Bordetella bronchiseptica, Glaesserella (Haemophilus) parasuis, Pasteurella multocida, Streptococcus suis, and Mycoplasma hyopneumoniae in weaned swine.
Single-Dose Field Intervention: Designed as a convenient “one-shot” treatment to halt aggressive respiratory outbreaks and get animals back on feed quickly.
To guarantee absolute safety, proper bioavailability, and tissue compatibility, Pradalex must be administered strictly according to approved species-specific routes and weight calculations.
1.Inspect Vial & Disinfect Septum:Aseptic Setup.
Inspect the $100\ \text{ml}$ multi-dose vial to ensure seal integrity. Swab the rubber stopper thoroughly with an antiseptic alcohol pad before drawing the solution into a sterile syringe.
2.Confirm Species-Specific Route:Route Selection.
Select the correct route carefully based on target livestock:
Cattle: Administer once as a subcutaneous (SQ) injection in the neck.
Swine: Administer once as an intramuscular (IM) injection in the neck.
3.Calculate Precise Body Weight Dose:Dosage Calculation.
Calculate volume strictly by body weight:
Cattle Dose: $2.3\ \text{mL}$ per $100\ \text{lbs}$ body weight ($10\ \text{mg/kg}$).
Swine Dose: $1.7\ \text{mL}$ per $100\ \text{lbs}$ body weight ($7.5\ \text{mg/kg}$).
4.Observe Site Volume Limits:Injection Limits.
To ensure optimal absorption, do not exceed $15\ \text{mL}$ per subcutaneous site in cattle or $5\ \text{mL}$ per intramuscular site in swine.

The table below outlines standard administration guidelines for Pradalex Injectable ($200\ \text{mg/mL}$):
| Target Species | Clinical Indication | Standard Dose Rate | Approved Route | Administration Schedule |
| Eligible Beef & Dairy Cattle | Bovine Respiratory Disease (BRD) | $2.3\ \text{mL}$ per $100\ \text{lbs}$ ($10\ \text{mg/kg}$) | Subcutaneous (SQ) in Neck | Single-dose treatment |
| Weaned Swine | Swine Respiratory Disease (SRD) | $1.7\ \text{mL}$ per $100\ \text{lbs}$ ($7.5\ \text{mg/kg}$) | Intramuscular (IM) in Neck | Single-dose treatment |
Veterinary Prescription Requirement: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Extra-label use in food-producing animals is strictly prohibited.
Class Restriction & Prudence: Use should be limited to the treatment of BRD and SRD only after consideration of other non-fluoroquinolone therapeutic options.
Age and Production Class Restrictions:
Cattle: Not for use in beef calves less than 2 months of age, dairy calves, veal calves, or female dairy cattle 1 year of age and older (including dry cows).
Swine: Not for use in nursing piglets or swine intended for breeding (replacement gilts, sows, or breeding boars).
Industry-Leading Slaughter Withdrawal Periods: Thanks to rapid systemic elimination, Pradalex features short pre-slaughter withdrawal times: 4 days for cattle and 2 days for swine.
Storage Parameters: Store at controlled room temperature at 25°C (77°F), with excursions permitted between -20°C and 40°C. Protect from direct sunlight; do not refrigerate or freeze. Use within 6 months of first puncture.
Pradalex contains Pradofloxacin at a high concentration of $200\ \text{mg/mL}$, functioning as an advanced third-generation fluoroquinolone antimicrobial.
Pradalex features a unique dual-action mechanism that simultaneously binds and inactivates both DNA gyrase and topoisomerase IV with equal affinity, resulting in faster bacterial cell death and a significantly reduced window for resistance selection.
Pradalex offers exceptional production flexibility with an industry-leading withdrawal period of 4 days for cattle and 2 days for swine destined for slaughter.
You can safely purchase authentic, veterinarian-approved Pradalex Injectable (100ml bottles) online through Equines Vet Care upon receipt of a valid veterinary prescription. We manage and store all prescription inventory under strict environmental controls to guarantee absolute product freshness, safety, and full potency.
At Equines Vet Care, we understand that managing complex respiratory outbreaks and safeguarding herd productivity requires access to the most advanced medical innovations. Every $100\ \text{ml}$ vial of Pradalex Injectable is sourced through authorized veterinary distribution networks, stored in our climate-controlled warehouse, and shipped securely to ensure complete product quality.
Pradalex Injectable is also for the treatment of swine respiratory disease (SRD) associated with Bordetella bronchiseptica, Glaesserella (Haemophilus) parasuis, Pasteurella multocida, Streptococcus suis, and Mycoplasma hyopneumoniae (M. hyo) in weaned swine intended for slaughter (nursery, growing, and finishing swine, boars, barrows, and gilts intended for slaughter, and sows intended for slaughter).
Directions:
For Cattle, administer once as a subcutaneous injection at a dosage of 2.3 ml per 100 lbs. body weight.
For Swine, administer once as an intramuscular injection in the neck at a dosage of 1.7 ml per 100 lbs. body weight.
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